William Kuo works with instruments, everyday objects, recorded sound, live audio processing, and video. Regardless of medium—acoustic, electroacoustic, or multimedia—he creates music that fluctuates between the sounding and the un-sounding, confronting physical and imaginary boundaries to contemplate notions of co-existence, embodiment, and unseen realities.

His music has been presented at Vancouver New Music, Klangspuren Festival, the C-LAB (Taiwan Sound Lab), Gaudeamus Muziekweek (Netherlands), Bludenzer Tage zeitgemäßer Musik (Austria), Cluster New Music Festival (Canada), Festival Voix Nouvelles (France), and ManiFeste (France). Apart from his activities as a composer, he has also performed as an electronic musician at Twenty Alpha in Hong Kong for the project Augmented Aurality, jointly created with Karen Yu. In 2022, Augmented Aurality was released as a full-length album under the Vintage Vinyl Hong Kong label.

Notable collaborators in recent years include Broken Frames Syndicate, Riot Ensemble, Talea Ensemble, TAK Ensemble, Ensemble Nikel, Quasar Quatuor de Saxophones, Ensemble Klang, Asko|Schönberg, Ensemble Mullatérale, Le Nouvel Ensemble Moderne, Ensemble InterContemporain, Ensemble Paramirabo, Orchestre Philharmonique de Radio France, Heather Roche, Eva Zöllner, Juliet Fraser, Juliette Adam, Karen Yu, and Jing-Mu Kuo.

He received his Bachelor's in Composition from McGill University in 2013 and his Master's in Composition from the Conservatoire de musique de Montréal in 2015. In 2018-19, he participated in the Cursus computer music program at IRCAM in Paris, France. He was a finalist for the Gaudeamus Award in 2018. In 2021, he was the artist-in-residence for the Taiwan Sound Lab Creators Sound-Off Residency. His work geht auf wie eine Blume was selected for the 2021 ISCM World New Music Days representing the Canadian section.